⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28058416 | 0.85 | — | — | |
| SCHEMBL1868510 | 0.78 | — | — | |
| SCHEMBL1864575 | 0.78 | — | — | |
| SCHEMBL1864577 | 0.78 | — | — | |
| SCHEMBL14434930 | 0.77 | MAPT (0.36) | — | |
| SCHEMBL2531872 | 0.76 | — | — | |
| SCHEMBL5966226 | 0.76 | POLB (0.36) | — | |
| SCHEMBL43215 | 0.76 | — | — | |
| SCHEMBL11038808 | 0.76 | MAPT (0.35) | — | |
| SCHEMBL11038803 | 0.76 | MAPT (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708273-B2 | Aryl methyl benzoquinazolinone M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2017-07-18 | — | — | US | disclosed |
| US-20160229813-A1 | ARYL METHYL BENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2016-08-11 | — | — | US | disclosed |
| US-20150031713-A1 | ARYL METHYL BENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2015-01-29 | — | — | US | disclosed |
| US-8883810-B2 | Aryl methyl benzoquinazolinone M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2014-11-11 | — | — | US | disclosed |
| US-20140005182-A1 | Aryl Methyl Benzoquinazolinone M1 Receptor Positive Allosteric Modulators | MERCK SHARP & DOHME CORP. (US) | 2014-01-02 | — | — | US | disclosed |
| US-8557832-B2 | Aryl methyl benzoquinazolinine M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2013-10-15 | — | — | US | disclosed |
| EP-2358686-B1 | ARYL METHYL BENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2012-09-26 | — | — | EP | disclosed |
| US-20110224198-A1 | ARYL METHYL BENZOQUINAZOLININE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME LLC | 2011-09-15 | — | — | US | disclosed |
| EP-2358686-A1 | ARYL METHYL BENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck Sharp & Dohme Corp. (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010059773-A1 | ARYL METHYL BENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2010-05-27 | — | — | WO | disclosed |
| CN-100337916-C | Hydrotalcite compound, process for producing the same, and agricultural film containing the same | KYOWA CHEM IND CO LTD (JP) | 2007-09-19 | — | — | CN | disclosed |
| CN-1140457-C | Fine-particle synthetic copper aluminite compound, its preparation method and application | Э�ͻ�ѧ��ҵ��ʽ���� | 2004-03-03 | — | — | CN | disclosed |
| CN-1289307-A | Hydrotalcite compound process for producing the same, and agricirultural film containing the same | KYOWA CHEM IND CO LTD (JP) | 2001-03-28 | — | — | CN | disclosed |
| CN-1253910-A | Fine-particle synthetic copper aluminite compound, its preparation method and application | KYOWA CHEM IND CO LTD (JP) | 2000-05-24 | — | — | CN | disclosed |
| US-5102963-A | Acrylate cured polyphosphazenes | ETHYL CORPORATION (US) | 1992-04-07 | — | — | US | disclosed |
| US-5001203-A | UV curable polyorganophosphazene composition | ETHYL CORPORATION (US) | 1991-03-19 | — | — | US | disclosed |
| EP-0334090-A2 | Acrylate cured polyphosphazenes | ETHYL CORPORATION (US) | 1989-09-27 | — | — | EP | disclosed |
| US-4816532-A | Acrylate cured polyphosphazenes | ETHYL CORPORATION (US) | 1989-03-28 | — | — | US | disclosed |