Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.50 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.47 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.47 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.39 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.39 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 2/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3702407 | 0.92 | LPAR1 (0.50) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL2335506 | 0.91 | LPAR1 (0.61) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL2335063 | 0.88 | LPAR1 (0.57) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL3705982 | 0.86 | LPAR1 (0.49) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL2294172 | 0.85 | LPAR1 (0.66) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL2294169 | 0.85 | LPAR1 (0.66) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL2636000 | 0.84 | LPAR1 (0.51) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL2338009 | 0.83 | LPAR1 (0.49) | LPAR1LPAR3LPAR2CYP2C9MAPT | |
| SCHEMBL3706823 | 0.83 | LPAR1 (0.49) | LPAR1LPAR3LPAR2ABCC3ABCC4 | |
| SCHEMBL2339547 | 0.83 | LPAR1 (0.56) | LPAR1LPAR3LPAR2ABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358688-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010077883-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |