Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.63 |
| ▸ | JAK3 | P52333 | 10/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.34 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2336362 | 0.89 | JAK2 (0.55) | JAK2JAK3KCNH2SYKPLK4 | |
| SCHEMBL783936 | 0.80 | JAK3 (0.61) | JAK2JAK3PLK4 | |
| SCHEMBL2332810 | 0.79 | KCNH2 (0.55) | JAK2JAK3KCNH2 | |
| SCHEMBL2338571 | 0.78 | JAK2 (0.46) | JAK2JAK3KCNH2PIK3CA | |
| SCHEMBL3008423 | 0.77 | JAK2 (1.00) | JAK2JAK3KCNH2 | |
| SCHEMBL251027 | 0.77 | JAK2 (0.51) | JAK2JAK3MAP2K7 | |
| SCHEMBL2161187 | 0.71 | JAK2 (0.74) | JAK2JAK3KCNH2 | |
| SCHEMBL4571027 | 0.71 | JAK2 (0.74) | JAK2JAK3KCNH2 | |
| SCHEMBL2339473 | 0.70 | JAK2 (1.00) | JAK2JAK3KCNH2 | |
| SCHEMBL589401 | 0.70 | JAK3 (0.62) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152702-B1 | AMINO-THIAZOLYL- PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2011-08-24 | — | — | EP | claimed |
| EP-2152702-B1 | AMINO-THIAZOLYL- PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2011-08-24 | — | — | EP | disclosed |