Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | JAK2 | O60674 | 8/20 | 0.44 |
| ▸ | JAK3 | P52333 | 4/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2336362 | 0.90 | JAK2 (0.55) | KCNH2JAK2JAK3GSK3AGSK3B | |
| SCHEMBL2337576 | 0.79 | JAK2 (0.63) | KCNH2JAK2JAK3 | |
| SCHEMBL2337030 | 0.77 | KCNH2 (0.44) | KCNH2JAK2JAK3GSK3AGSK3B | |
| SCHEMBL589401 | 0.72 | JAK3 (0.62) | JAK2JAK3 | |
| SCHEMBL3732373 | 0.69 | HRH4 (0.49) | KCNH2HRH4HRH3 | |
| SCHEMBL2338571 | 0.67 | JAK2 (0.46) | KCNH2JAK2JAK3GSK3AGSK3B | |
| SCHEMBL2337358 | 0.67 | GSK3A (0.42) | KCNH2JAK2JAK3GSK3AGSK3B | |
| SCHEMBL1366207 | 0.66 | JAK2 (0.43) | KCNH2JAK2JAK3KDM4EALDH1A1 | |
| SCHEMBL12973632 | 0.64 | KCNH2 (0.59) | KCNH2JAK2JAK3KDM4EMEN1 | |
| SCHEMBL2334912 | 0.64 | NTRK1 (0.59) | KCNH2JAK2JAK3GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152702-B1 | AMINO-THIAZOLYL- PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2011-08-24 | — | — | EP | claimed |
| EP-2152702-B1 | AMINO-THIAZOLYL- PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2011-08-24 | — | — | EP | disclosed |