Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 12/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | LTK | P29376 | 1/20 | 0.31 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2343779 | 0.89 | MAPK1 (0.36) | MAPK1SYKCYP2D6JAK3KCNH2 | |
| SCHEMBL1887883 | 0.78 | JAK3 (0.51) | MAPK1SYKCYP2D6JAK3KCNH2 | |
| SCHEMBL3396668 | 0.76 | KIT (0.36) | CYP2D6JAK3MAP4K4NTRK1CLK4 | |
| SCHEMBL3396373 | 0.74 | JAK3 (0.44) | MAPK1JAK3MAP4K4PTK2 | |
| SCHEMBL3396005 | 0.72 | SCN9A (0.42) | MAPK1SYKCYP2D6JAK3 | |
| SCHEMBL3396270 | 0.72 | CDK8 (0.48) | MAPK1SYKCYP2D6JAK3MAP4K4 | |
| SCHEMBL3398976 | 0.72 | MAPK1 (0.49) | MAPK1SYKCYP2D6JAK3CLK2 | |
| SCHEMBL3393845 | 0.72 | MAPK1 (0.38) | MAPK1SYKCYP2D6JAK3CDK8 | |
| SCHEMBL3399095 | 0.71 | CDK8 (0.42) | MAPK1SYKCYP2D6JAK3CDK8 | |
| SCHEMBL3397956 | 0.70 | MAPK1 (0.42) | MAPK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247592-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |