Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 8/20 | 0.38 |
| ▸ | JAK3 | P52333 | 4/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3396270 | 0.84 | CDK8 (0.48) | MAPK1JAK3SYKCYP2D6BTK | |
| SCHEMBL3399095 | 0.82 | CDK8 (0.42) | MAPK1JAK3SYKCYP2D6BTK | |
| SCHEMBL2280912 | 0.81 | JAK3 (0.55) | MAPK1JAK3SYKCYP2D6 | |
| SCHEMBL3396005 | 0.77 | SCN9A (0.42) | MAPK1JAK3SYKCYP2D6 | |
| SCHEMBL3398976 | 0.77 | MAPK1 (0.49) | MAPK1JAK3SYKCYP2D6CLK1 | |
| SCHEMBL3396373 | 0.74 | JAK3 (0.44) | MAPK1JAK3BTKITK | |
| SCHEMBL3399596 | 0.73 | JAK2 (0.41) | JAK3 | |
| SCHEMBL2337979 | 0.72 | MAPK1 (0.37) | MAPK1JAK3SYKCYP2D6DYRK1A | |
| SCHEMBL2341240 | 0.71 | LRRK2 (0.38) | MAPK1JAK3SYK | |
| SCHEMBL3397956 | 0.71 | MAPK1 (0.42) | MAPK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | claimed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |