Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.52 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.52 |
| ▸ | BRD4 | O60885 | 4/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18667645 | 0.77 | CRBN (0.43) | GRIA1CACNG8BRD4CREBBPCRBN | |
| SCHEMBL21483771 | 0.75 | GRIA1 (0.66) | GRIA1CACNG8BRD4CREBBPCRBN | |
| SCHEMBL7710607 | 0.74 | KCNA5 (0.52) | BRD4CREBBPKCNA5HDAC1 | |
| SCHEMBL7791651 | 0.74 | KCNA5 (0.54) | KCNA5HDAC1AKT1 | |
| SCHEMBL12050574 | 0.74 | KCNA5 (0.54) | KCNA5HDAC1AKT1 | |
| SCHEMBL3750932 | 0.74 | KCNA5 (0.54) | KCNA5DRD2HDAC1 | |
| SCHEMBL5477445 | 0.74 | CHRM1 (0.56) | BRD4CREBBPKCNA5HDAC1 | |
| SCHEMBL25470419 | 0.74 | KCNA5 (0.51) | BRD4CREBBPALOX5APFEN1KCNA5 | |
| SCHEMBL3413608 | 0.73 | KCNA5 (0.51) | KCNA5HDAC1 | |
| SCHEMBL7862318 | 0.73 | KCNA5 (0.53) | KCNA5HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210147427-A1 | PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITOR OF CYCLIN DEPENDENT KINASE | LEAD DISCOVERY CENTER GMBH (DE) | 2021-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210147427-A1 | PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITOR OF CYCLIN DEPENDENT KINASE | CDK1, CDK2, CDK15 | GRIA1 2606/4885CACNG8 4003/4885BRD4 377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.