Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.56 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7710607 | 0.86 | KCNA5 (0.52) | CHRM1CHRM3KCNA5KDM4ABRD4 | |
| SCHEMBL25470419 | 0.85 | KCNA5 (0.51) | CHRM1CHRM3KCNA5KDM4ABRD4 | |
| SCHEMBL4060683 | 0.84 | KCNA5 (0.50) | CHRM1CHRM3KCNA5KDM4ABRD4 | |
| SCHEMBL31710569 | 0.84 | KCNA5 (0.50) | KCNA5KDM4ABRD4CREBBPHDAC1 | |
| SCHEMBL3416541 | 0.83 | KCNA5 (0.49) | KCNA5KDM4ABRD4CREBBPHDAC1 | |
| SCHEMBL3410533 | 0.81 | KCNA5 (0.50) | KCNA5KDM4ABRD4CREBBPNQO2 | |
| SCHEMBL12050574 | 0.79 | KCNA5 (0.54) | CHRM3KCNA5KDM4ANQO2HDAC1 | |
| SCHEMBL7791651 | 0.79 | KCNA5 (0.54) | KCNA5KDM4AIDO1HDAC1NAMPT | |
| SCHEMBL3750932 | 0.79 | KCNA5 (0.54) | KCNA5HTR7KDM4AHDAC1 | |
| SCHEMBL30159605 | 0.78 | KCNA5 (0.56) | KCNA5KDM4AIDO1NQO2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070099927-A1 | Aminoalkyl-pyrazinones and-pyridones as thrombin inhibitors | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2007-05-03 | — | — | US | disclosed |
| WO-2005040137-A1 | AMINOALKYL-PYRAZINONES AND -PYRIDONES AS THROMBIN INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2005-05-06 | — | — | WO | disclosed |
| EP-1526131-A1 | Aminoalkyl-pyrazinones and -pyridones as thrombin inhibitors | Graffinity Pharmaceuticals Aktiengesellschaft (DE) | 2005-04-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099927-A1 | Aminoalkyl-pyrazinones and-pyridones as thrombin inhibitors | F2, F12, SERPINC1 | CHRM1 1019/4885CHRM3 1657/4885KCNA5 663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.