Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 8/20 | 0.39 |
| ▸ | ABL1 | P00519 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.38 |
| ▸ | YES1 | P07947 | 3/20 | 0.38 |
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | HIPK1 | Q86Z02 | 3/20 | 0.38 |
| ▸ | NEK2 | P51955 | 2/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2278229 | 0.93 | SYK (0.47) | SYKCYP2C9JAK3ABL1KDR | |
| SCHEMBL2274208 | 0.85 | JAK3 (0.44) | SYKCYP2C9JAK3MAP4K1JAK2 | |
| SCHEMBL2279556 | 0.84 | JAK3 (0.44) | SYKCYP2C9JAK3MAP4K1JAK2 | |
| SCHEMBL2278364 | 0.84 | JAK3 (0.44) | SYKCYP2C9JAK3MAP4K1KCNH2 | |
| SCHEMBL2276778 | 0.84 | JAK3 (0.45) | SYKCYP2C9JAK3MAP4K1KCNH2 | |
| SCHEMBL2276394 | 0.83 | JAK3 (0.49) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2279681 | 0.83 | JAK3 (0.43) | SYKCYP2C9JAK3MAP4K1JAK2 | |
| SCHEMBL2279856 | 0.83 | SYK (0.45) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2278269 | 0.81 | JAK3 (0.43) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2349552 | 0.80 | JAK3 (0.46) | SYKCYP2C9JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | disclosed |