Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24659 | 0.83 | — | — | |
| SCHEMBL15221252 | 0.81 | PDE10A (0.38) | FLT3HTR6 | |
| SCHEMBL19266 | 0.77 | KDR (0.48) | — | |
| SCHEMBL20035 | 0.76 | JAK2 (0.51) | — | |
| SCHEMBL20918 | 0.74 | FLT1 (0.42) | — | |
| SCHEMBL15210382 | 0.74 | JAK2 (0.53) | — | |
| SCHEMBL16394606 | 0.74 | CDK19 (0.44) | FLT3 | |
| SCHEMBL15221144 | 0.74 | JAK2 (0.46) | — | |
| SCHEMBL21018 | 0.73 | NFKB1 (0.51) | — | |
| SCHEMBL15221233 | 0.73 | JAK2 (0.60) | FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817310-B1 | 8-SUBSTITUTED 2-AMINO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |
| WO-2012025186-A1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |