Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 7/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.46 |
| ▸ | KDM6B | O15054 | 4/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23396886 | 0.91 | ADAMTS4 (0.39) | ADAMTS4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL23396959 | 0.84 | HRH4 (0.47) | ADAMTS4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL23396915 | 0.80 | ADAMTS4 (0.43) | ADAMTS4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL23397007 | 0.80 | ADAMTS4 (0.44) | ADAMTS4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL23396856 | 0.75 | ADAMTS4 (0.37) | ADAMTS4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL18743015 | 0.73 | GRIN2D (0.53) | ADAMTS4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL23396976 | 0.73 | DYRK1A (0.43) | — | |
| SCHEMBL2954351 | 0.72 | MKNK1 (0.55) | ADAMTS4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2954481 | 0.70 | GRIN2D (0.51) | ADAMTS4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL23396830 | 0.70 | AAK1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3359154-B1 | WNT SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF | Suzhou Yunxuan Yiyao Keji Youxian Gongsi (CN) | 2021-05-26 | — | — | EP | disclosed |