Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.41 |
| ▸ | FABP1 | P07148 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3282205 | 0.86 | MAPK14 (0.59) | MAPK14FABP1 | |
| SCHEMBL3526112 | 0.83 | HSP90AB1 (0.41) | MAPK14FABP1MAPK13MAPK12MAPK11 | |
| SCHEMBL1065104 | 0.83 | HSP90AB1 (0.42) | MAPK14FABP1MAPK13MAPK12MAPK11 | |
| SCHEMBL5225468 | 0.79 | MAPK14 (0.60) | MAPK14FABP1MAPK11 | |
| SCHEMBL5227603 | 0.77 | MAPK14 (0.53) | MAPK14FABP1PTGS2BRD4MAPK13 | |
| SCHEMBL1065731 | 0.76 | MAPK14 (0.40) | MAPK14HTR7 | |
| SCHEMBL5229479 | 0.74 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5227756 | 0.74 | MAPK14 (0.54) | MAPK14FABP1PTGS2MAPK13MAPK12 | |
| SCHEMBL1059157 | 0.73 | MAPK14 (0.49) | MAPK14FABP1PTGS2BRD4MAPK13 | |
| SCHEMBL5229767 | 0.72 | MAPK14 (0.61) | MAPK14MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1333833-B1 | Novel trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compound for the treatment of CSBP/p38 kinase mediated diseases | GLAXOSMITHKLINE LLC (US) | 2011-08-24 | — | — | EP | claimed |