SCHEMBL23402107

SCHEMBL23402107

Cc1ccc(-n2nc(C)c(-c3ccccc3)c2O)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 9/20 0.55
RAB9A P51151 9/20 0.55
SMN1; SMN2 Q16637 9/20 0.55
MAPT P10636 9/20 0.52
TP53 P04637 2/20 0.52
ALDH1A1 P00352 4/20 0.48
KMT2A Q03164 3/20 0.48
NPSR1 Q6W5P4 2/20 0.48
MEN1 O00255 2/20 0.48
MAPK1 P28482 1/20 0.48
NFKB1 P19838 1/20 0.47
NFKB2 Q00653 1/20 0.47
RELA Q04206 1/20 0.47
POLB P06746 2/20 0.44
TDP1 Q9NUW8 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
CYP1A2 P05177 2/20 0.44
CYP2C9 P11712 2/20 0.44
CYP2C19 P33261 2/20 0.44
STAT1 P42224 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23398925 0.94 SMN1; SMN2 (0.55) NPC1RAB9ASMN1; SMN2MAPTTP53
SCHEMBL23401877 0.92 SMN1; SMN2 (0.47) NPC1RAB9ASMN1; SMN2MAPTTP53
SCHEMBL14132909 0.92 SMN1; SMN2 (0.65) NPC1RAB9ASMN1; SMN2MAPTTP53
SCHEMBL23398623 0.87 MEN1 (0.48) NPC1RAB9ASMN1; SMN2MAPTTP53
SCHEMBL23399683 0.86 CCNA2 (0.49) NPC1RAB9ASMN1; SMN2MAPTTP53
SCHEMBL23403434 0.86 CCNA2 (0.49) NPC1RAB9ASMN1; SMN2MAPTTP53
SCHEMBL23398488 0.85 ALDH1A1 (0.41) NPC1RAB9ASMN1; SMN2MAPTTP53
SCHEMBL23403276 0.83 CA1 (0.50) NPC1RAB9ASMN1; SMN2MAPTTP53
SCHEMBL23398517 0.83 RPA1 (0.52) NPC1RAB9ASMN1; SMN2MAPTTP53
SCHEMBL8081936 0.83 SMN1; SMN2 (0.56) NPC1RAB9ASMN1; SMN2MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3828159-A1 STORAGE AND TRANSPORT STABILIZERS FOR POLYMERIZABLE COMPOUNDS BASF SE (DE) 2021-06-02 EP disclosed