Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPR3 | P17342 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | ANPEP | P15144 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | LAP3 | P28838 | 1/20 | 0.35 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.35 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.35 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2340287 | 1.00 | NPR3 (0.38) | NPR3HIF1AMAPK14MAPK13MAPK12 | |
| SCHEMBL2340290 | 1.00 | NPR3 (0.38) | NPR3HIF1AMAPK14MAPK13MAPK12 | |
| SCHEMBL12374513 | 0.91 | NPR3 (0.39) | NPR3HIF1AMAPK14MAPK13MAPK12 | |
| SCHEMBL14204179 | 0.91 | NPR3 (0.39) | NPR3HIF1AMAPK14MAPK13MAPK12 | |
| SCHEMBL12858426 | 0.84 | HIF1A (0.34) | HIF1AHDAC4HDAC3HDAC1HDAC7 | |
| SCHEMBL2282699 | 0.83 | MAPK14 (0.45) | NPR3HIF1AMAPK14MAPK13MAPK12 | |
| SCHEMBL2282683 | 0.83 | MAPK14 (0.45) | NPR3HIF1AMAPK14MAPK13MAPK12 | |
| SCHEMBL1147484 | 0.80 | CACNA1B (0.44) | HIF1AAAK1CTSSCTSK | |
| SCHEMBL1147480 | 0.80 | CACNA1B (0.44) | HIF1AAAK1CTSSCTSK | |
| SCHEMBL2276126 | 0.79 | NPR3 (0.37) | NPR3HIF1AMAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078007-B1 | IKK-BETA SERINE-THREONINE PROTEIN KINASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2011-08-31 | — | — | EP | disclosed |