NPR3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL17424044	0.78	6/20
SCHEMBL6530463	0.55	6/20
SCHEMBL6530469	0.55	6/20
SCHEMBL12215074	0.58	5/20
SCHEMBL5634567	0.50	5/20
SCHEMBL5634570	0.50	5/20
SCHEMBL6529224	0.56	4/20
SCHEMBL5906846	0.55	4/20
SCHEMBL3122959	0.53	4/20
SCHEMBL11290439	0.49	4/20
SCHEMBL13021673	0.34	4/20
SCHEMBL30437754	0.55	3/20
SCHEMBL5906830	0.52	3/20
SCHEMBL5906925	0.51	3/20
SCHEMBL5906929	0.51	3/20
SCHEMBL17203151	0.47	3/20
SCHEMBL17203152	0.47	3/20
SCHEMBL10210577	0.45	3/20
SCHEMBL12627973	0.45	3/20
SCHEMBL15524534	0.42	3/20

Clinical trials — most relevant to NPR3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study Of The Usage Of Statins In A Community Heart Failure Population	PHASE4	COMPLETED
Effect of Renal deNervation on Arterial Stiffness and Haemodynamics in Patients With UncontRolled hypErtension (ENSURE)	PHASE4	UNKNOWN
Dose-comparison Study of Prednisone in Heart Failure	PHASE3	COMPLETED
A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide), Placebo or Intravenous Nitroglycerin to Standard Care for the Treatment of Worsening Congestive Heart Failure.	PHASE3	COMPLETED
The Effects of Sacubitril/Valsartan Compared to Valsartan on LV Remodelling in Asymptomatic LV Systolic Dysfunction After MI	PHASE3	COMPLETED
The Effects of Atorvastatin on the Nitric Oxide-system in Healthy Young Man	PHASE2	COMPLETED
Race, Natriuretic Peptides and Physiological Perturbations	PHASE2	COMPLETED
Effects of Chimeric Natriuretic Peptide Versus Placebo in Stable Heart Failure and Moderate Renal Dysfunction	PHASE1	WITHDRAWN
BNP Pharmacodynamics and Effects on Metabolism in Lean and Obese Subjects	PHASE1	COMPLETED
Effects of Different Forms of a Natural Heart Hormone on Blood Pressure and Fluid Balance in Healthy Volunteers	EARLY_PHASE1	COMPLETED
Relationship of Brain Natriuretic Peptide (BNP) Levels to Cardiac Diagnosis, Operation Performed, Post-operative Course and Outcome	nan	COMPLETED
Ankle Brachial Index Versus Conventional Cardiac Risk Indices	nan	UNKNOWN
C-Type Natriuretic Peptide and Achondroplasia	nan	COMPLETED
Diagnostic and Prognostic Role of Troponin and Brain Natriuretic Peptide in Pediatric Patients With Cardiomyopathy in Correlation to Echocardiography Findings	nan	UNKNOWN
Pharmacogenomics in Pulmonary Arterial Hypertension	nan	WITHDRAWN
A Biomarker to Detect Salt Sensitivity	nan	COMPLETED
Analysis of Cardiac Biomarker Racial Discrepancies	nan	ENROLLING_BY_INVITATION
Qatar Cardiovascular Biorepository of AF Patients	nan	UNKNOWN
Neurological Prognostication of Patients in Therapeutic Hypothermia After Cardiac Arrest	nan	COMPLETED
B-type Natriuretic Peptide as a Surrogate Marker Guiding Post-operative Fluid Off-loading	nan	COMPLETED
The Natriuretic Peptide System in African-Americans.	nan	COMPLETED
GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study	nan	RECRUITING
A Cut-off Value Study of N-terminal Brain Natriuretic Peptide （Chemiluminescence Method）	nan	COMPLETED
Heart Failure in the Community	nan	COMPLETED
ARgentinean Risk Assessment Registry in ACS; the ARRA-RACS Study	nan	COMPLETED
Effects of Nesiritide in Pediatric Patients With Heart Failure	nan	WITHDRAWN
Comparison of BNP and NT-proBNP in the Management of Patients With Chronic and Acute Heart Failure	nan	UNKNOWN
The Influence of NPPA/NPPB Haplotype on Natriuretic Peptide Plasma Levels	nan	COMPLETED
Idiopathic Dilated Cardiomyopathy	nan	COMPLETED
The Diurnal Rhythm in Natriuretic Peptide Levels	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NPR3 binder may also engage these)

Protein	Name	Similarity
P10730	—	1.000	P10730 →
P41740	—	1.000	P41740 →
P70180	—	0.997	P70180 →
Q86GV3	—	0.990	Q86GV3 →
O02740	—	0.989	O02740 →
Q80T41	—	0.989	Q80T41 →
Q9GYQ4	—	0.988	Q9GYQ4 →
A8WPG9	—	0.986	A8WPG9 →
O16544	—	0.986	O16544 →
Q5SDA5	—	0.986	Q5SDA5 →
Q23681	—	0.985	Q23681 →
P11528	—	0.985	P11528 →
N1NVB7	—	0.985	N1NVB7 →
Q09435	—	0.984	Q09435 →
Q7JQ32	—	0.984	Q7JQ32 →
P55205	—	0.983	P55205 →
Q23310	—	0.983	Q23310 →
Q7XP59	—	0.983	Q7XP59 →
Q6TL19	—	0.983	Q6TL19 →
P51842	—	0.983	P51842 →
MBTPS1	Membrane-bound transcription factor site-1 protease	0.983	landscape →
Q23682	—	0.982	Q23682 →
Q75ZY9	—	0.981	Q75ZY9 →
P55203	—	0.981	P55203 →
G5ECB2	—	0.981	G5ECB2 →
P23897	—	0.981	P23897 →
Q2QLA9	—	0.981	Q2QLA9 →
Q07DZ1	—	0.981	Q07DZ1 →
Q27675	—	0.981	Q27675 →
P91550	—	0.981	P91550 →