Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.54 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29743831 | 1.00 | ADORA3 (0.57) | ADORA3NPC1RAB9AS1PR3TLR7 | |
| SCHEMBL29744073 | 0.90 | F2 (0.58) | ADORA3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL20641503 | 0.90 | F2 (0.58) | ADORA3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL29743834 | 0.87 | ADORA1 (0.60) | ADORA3MEN1KMT2APOLBKDM4E | |
| SCHEMBL23405931 | 0.87 | ADORA1 (0.60) | ADORA3MEN1KMT2APOLBKDM4E | |
| SCHEMBL23406072 | 0.86 | DEGS1 (0.63) | ADORA3NPC1RAB9AS1PR3MEN1 | |
| SCHEMBL23406009 | 0.86 | GRM1 (0.57) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29744146 | 0.86 | DEGS1 (0.63) | ADORA3NPC1RAB9AS1PR3MEN1 | |
| SCHEMBL29744058 | 0.86 | GRM1 (0.57) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23406002 | 0.86 | TRPV1 (0.52) | RAB9AKMT2ATRPV1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11377436-B2 | EAAT2 enhancing molecules | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2022-07-05 | — | — | US | disclosed |
| US-11377436-B2 | EAAT2 enhancing molecules | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2022-07-05 | — | — | US | disclosed |
| US-20210163440-A1 | EAAT2 ENHANCING MOLECULES | BRIGHAM & WOMENS HOSPITAL INC (US) | 2021-06-03 | — | — | US | disclosed |
| US-20210163440-A1 | EAAT2 ENHANCING MOLECULES | BRIGHAM & WOMENS HOSPITAL INC (US) | 2021-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163440-A1 | EAAT2 ENHANCING MOLECULES | SLC1A2, SLC1A1, SLC1A3 | ADORA3 208/4885NPC1 350/4885RAB9A 1985/4885 |
| US-11377436-B2 | EAAT2 enhancing molecules | SLC1A2, SLC1A1, SLC1A3 | ADORA3 208/4885NPC1 350/4885RAB9A 1985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.