Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.62 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 3/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.57 |
| ▸ | BCR | P11274 | 2/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.57 |
| ▸ | CLK1 | P49759 | 1/20 | 0.57 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29743850 | 0.85 | DEGS1 (0.73) | LMNACYP11B1CYP11B2DYRK1ACLK1 | |
| SCHEMBL23405953 | 0.85 | DEGS1 (0.73) | LMNACYP11B1CYP11B2DYRK1ACLK1 | |
| SCHEMBL14082509 | 0.82 | CYP11B1 (0.72) | LMNACYP11B1CYP11B2ABL1PDGFRB | |
| SCHEMBL20653088 | 0.82 | CYP11B1 (0.72) | LMNACYP11B1CYP11B2ABL1PDGFRB | |
| SCHEMBL29744015 | 0.82 | CYP11B1 (0.72) | LMNACYP11B1CYP11B2ABL1PDGFRB | |
| SCHEMBL14527311 | 0.80 | MKNK1 (0.66) | LMNACYP11B1CYP11B2ABL1BCR | |
| SCHEMBL29743951 | 0.80 | PTPN1 (0.73) | LMNACYP11B1CYP11B2ABL1PDGFRB | |
| SCHEMBL20653227 | 0.80 | PTPN1 (0.73) | LMNACYP11B1CYP11B2ABL1PDGFRB | |
| SCHEMBL20653084 | 0.79 | LMNA (0.68) | LMNACYP11B1CYP11B2ABL1PDGFRB | |
| SCHEMBL29743884 | 0.79 | LMNA (0.68) | LMNACYP11B1CYP11B2ABL1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11377436-B2 | EAAT2 enhancing molecules | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2022-07-05 | — | — | US | disclosed |
| US-11377436-B2 | EAAT2 enhancing molecules | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2022-07-05 | — | — | US | disclosed |
| US-20210163440-A1 | EAAT2 ENHANCING MOLECULES | BRIGHAM & WOMENS HOSPITAL INC (US) | 2021-06-03 | — | — | US | disclosed |
| US-20210163440-A1 | EAAT2 ENHANCING MOLECULES | BRIGHAM & WOMENS HOSPITAL INC (US) | 2021-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163440-A1 | EAAT2 ENHANCING MOLECULES | SLC1A2, SLC1A1, SLC1A3 | LMNA 4504/4885CYP11B1 2145/4885CYP11B2 1678/4885 |
| US-11377436-B2 | EAAT2 enhancing molecules | SLC1A2, SLC1A1, SLC1A3 | LMNA 4504/4885CYP11B1 2145/4885CYP11B2 1678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.