Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23389776 | 0.86 | TGFBR1 (0.43) | TGFBR1MTORCYP2D6TGFBR2MAP3K20 | |
| SCHEMBL29796572 | 0.86 | TGFBR1 (0.43) | TGFBR1MTORCYP2D6TGFBR2MAP3K20 | |
| SCHEMBL23408112 | 0.84 | TGFBR1 (0.43) | TGFBR1MTORCYP2D6TGFBR2MAP3K20 | |
| SCHEMBL29796624 | 0.81 | TGFBR1 (0.42) | TGFBR1MTORCYP2D6TGFBR2MAP3K20 | |
| SCHEMBL23389914 | 0.81 | TGFBR1 (0.42) | TGFBR1MTORCYP2D6TGFBR2MAP3K20 | |
| SCHEMBL4068870 | 0.81 | TGFBR1 (0.61) | TGFBR1MTORMAPK14CCR1CCR8 | |
| SCHEMBL30155653 | 0.79 | TGFBR1 (0.39) | TGFBR1MTORCYP2D6TGFBR2MAP3K20 | |
| SCHEMBL25084809 | 0.79 | TGFBR1 (0.39) | TGFBR1MTORCYP2D6TGFBR2MAP3K20 | |
| SCHEMBL23418587 | 0.78 | TGFBR1 (0.42) | TGFBR1MTORMAPK14CCR1CCR8 | |
| SCHEMBL25084786 | 0.77 | TGFBR1 (0.39) | TGFBR1MTORCYP2D6TGFBR2MAP3K20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021102468-A1 | SUBSTITUTED 1,5-NAPHTHYRIDINES OR QUINOLINES AS ALK5 INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2021-05-27 | — | — | WO | disclosed |