Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | ROS1 | P08922 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23408617 | 0.87 | MAPT (0.41) | IRAK4NTRK1PIM1MAPTAAK1 | |
| SCHEMBL23408809 | 0.84 | PIM1 (0.33) | IRAK4PIM1AAK1DYRK3CCNT1 | |
| SCHEMBL23408679 | 0.83 | NTRK1 (0.35) | NTRK1PIM1MAPTAAK1NTRK3 | |
| SCHEMBL23408591 | 0.80 | NTRK1 (0.49) | NTRK1 | |
| SCHEMBL23408695 | 0.80 | NTRK1 (0.49) | NTRK1 | |
| SCHEMBL23408737 | 0.78 | NTRK1 (0.40) | IRAK4NTRK1ABL1CDK4CDK6 | |
| SCHEMBL23408817 | 0.77 | IRAK4 (0.36) | IRAK4NTRK1PIM1MAPTAAK1 | |
| SCHEMBL23408585 | 0.77 | IRAK4 (0.36) | IRAK4NTRK1PIM1MAPTAAK1 | |
| SCHEMBL23408752 | 0.76 | DYRK1A (0.35) | IRAK4PIM1AAK1DYRK3CCNT1 | |
| SCHEMBL23408584 | 0.76 | DYRK1A (0.35) | IRAK4PIM1AAK1DYRK3CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021098745-A1 | PREPARATION AND APPLICATION OF A CLASS OF PROTEIN RECEPTOR KINASE INHIBITORS | 上海轶诺药业有限公司 | 2021-05-27 | — | — | WO | disclosed |