Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.40 |
| ▸ | CDK4 | P11802 | 12/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23408813 | 0.89 | NTRK1 (0.45) | NTRK1ABL1IRAK4 | |
| SCHEMBL23408581 | 0.84 | IRAK4 (0.39) | NTRK1ABL1IRAK4 | |
| SCHEMBL23408621 | 0.80 | NTRK1 (0.56) | NTRK1 | |
| SCHEMBL22084288 | 0.78 | NTRK1 (0.46) | NTRK1IRAK4 | |
| SCHEMBL23408626 | 0.78 | IRAK4 (0.38) | NTRK1CDK4CDK6ABL1IRAK4 | |
| SCHEMBL22084290 | 0.77 | NTRK1 (0.44) | NTRK1IRAK4 | |
| SCHEMBL22084170 | 0.74 | NTRK1 (0.45) | NTRK1ABL1IRAK4 | |
| SCHEMBL22083695 | 0.73 | NTRK1 (0.41) | NTRK1IRAK4 | |
| SCHEMBL29618143 | 0.72 | NTRK1 (0.60) | NTRK1 | |
| SCHEMBL23408640 | 0.71 | PIM1 (0.40) | NTRK1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021098745-A1 | PREPARATION AND APPLICATION OF A CLASS OF PROTEIN RECEPTOR KINASE INHIBITORS | 上海轶诺药业有限公司 | 2021-05-27 | — | — | WO | disclosed |