Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 15/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.54 |
| ▸ | THRB | P10828 | 3/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
| ▸ | ABL2 | P42684 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2044324 | 0.91 | TGFBR1 (0.47) | TGFBR1MAPK14THRBACVR1TGFBR2 | |
| SCHEMBL376179 | 0.84 | TGFBR1 (0.67) | TGFBR1MAPK14THRBACVR1TGFBR2 | |
| SCHEMBL373271 | 0.83 | TGFBR1 (0.59) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| Fluoromethane SCHEMBL27755992 | 0.82 | TGFBR1 (0.64) | TGFBR1MAPK14THRBACVR1TGFBR2 | |
| SCHEMBL29547877 | 0.80 | TGFBR1 (0.56) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL29504909 | 0.80 | TGFBR1 (0.56) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL373665 | 0.80 | TGFBR1 (0.56) | TGFBR1MAPK14THRBTGFBR2ABL2 | |
| SCHEMBL2049077 | 0.80 | TGFBR1 (0.43) | TGFBR1MAPK14THRB | |
| SCHEMBL373583 | 0.76 | MAPK14 (0.55) | TGFBR1MAPK14ACVR1TGFBR2ABL2 | |
| SCHEMBL18292297 | 0.73 | NFATC1 (0.51) | TGFBR1MAPK14ACVR1TGFBR2ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114787145-B | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 阿戈麦布西班牙股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| EP-4065572-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | Origo Biopharma, S.L. (ES) | 2022-10-05 | — | — | EP | disclosed |
| CN-114787145-A | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 奥里戈生物制药有限公司 | 2022-07-22 | — | — | CN | disclosed |
| WO-2021105317-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | ORIGO BIOPHARMA, S.L. (ES) | 2021-06-03 | — | — | WO | disclosed |