Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 8/20 | 0.39 |
| ▸ | JAK2 | O60674 | 5/20 | 0.39 |
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
| ▸ | SYK | P43405 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2341691 | 0.91 | SYK (0.43) | JAK3JAK2JAK1SYKCYP2C9 | |
| SCHEMBL2344717 | 0.88 | SYK (0.37) | JAK3SYKCYP2C9PRKCIMAP4K1 | |
| SCHEMBL2280571 | 0.87 | JAK3 (0.54) | JAK3JAK2JAK1SYKCYP2C9 | |
| SCHEMBL2348276 | 0.85 | SYK (0.38) | SYKPRKCIMAP4K1 | |
| SCHEMBL2349820 | 0.84 | ATR (0.45) | JAK3JAK2PRKCIATR | |
| SCHEMBL2350193 | 0.84 | SYK (0.38) | JAK3JAK2JAK1SYKCYP2C9 | |
| SCHEMBL2344505 | 0.84 | MAP4K1 (0.36) | JAK3SYKCYP2C9PRKCIMAP4K1 | |
| SCHEMBL2275385 | 0.81 | SYK (0.55) | JAK3JAK2JAK1SYKCYP2C9 | |
| SCHEMBL2343568 | 0.79 | CNR2 (0.40) | JAK2SYKATR | |
| SCHEMBL2282175 | 0.79 | JAK3 (0.51) | JAK3SYKCYP2C9PRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |