Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2348276 | 0.92 | SYK (0.38) | SYKCYP2D6KCNH2PRKCIMAP4K1 | |
| SCHEMBL2349020 | 0.89 | SYK (0.41) | SYKCYP2D6KCNH2PRKCIMAP4K1 | |
| SCHEMBL2341691 | 0.88 | SYK (0.43) | SYKPRKCIMAP4K1JAK3CYP2C9 | |
| SCHEMBL2341503 | 0.88 | JAK3 (0.39) | SYKPRKCIMAP4K1ATRJAK3 | |
| SCHEMBL2349820 | 0.88 | ATR (0.45) | PRKCIATRJAK3 | |
| SCHEMBL2344505 | 0.87 | MAP4K1 (0.36) | SYKCYP2D6PRKCIMAP4K1ATR | |
| SCHEMBL2278920 | 0.86 | SYK (0.50) | SYKCYP2D6KCNH2 | |
| SCHEMBL2350193 | 0.84 | SYK (0.38) | SYKPRKCIMAP4K1ATRMAPK1 | |
| SCHEMBL2362648 | 0.83 | JAK3 (0.36) | SYKCYP2D6KCNH2MAP4K1ATR | |
| SCHEMBL2343568 | 0.82 | CNR2 (0.40) | SYKATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |