Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17073448 | 0.80 | TACR1 (0.47) | RAB9ACYP3A4 | |
| SCHEMBL23429069 | 0.75 | KLKB1 (0.44) | NPC1 | |
| SCHEMBL23429132 | 0.74 | SIGMAR1 (0.43) | — | |
| SCHEMBL3397976 | 0.72 | HPGD (0.43) | ALDH1A1HPGDRAB9APKMCYP3A4 | |
| SCHEMBL9185050 | 0.71 | MTOR (0.52) | ALDH1A1HPGDRAB9APKMCYP3A4 | |
| SCHEMBL9729131 | 0.71 | HPGD (0.55) | ALDH1A1HPGDGAARAB9APKM | |
| SCHEMBL14492278 | 0.71 | ATM (0.70) | HPGDGAANPC1RAB9APKM | |
| SCHEMBL17073430 | 0.70 | KLKB1 (0.42) | ALDH1A1NPC1 | |
| SCHEMBL23429097 | 0.70 | GAA (0.50) | ALDH1A1HPGDGAANPC1RAB9A | |
| SCHEMBL25665861 | 0.70 | GAA (0.50) | ALDH1A1HPGDGAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4180424-A1 | SUBSTITUTED PYRAZOLES AS HUMAN PLASMA KALLIKREIN INHIBITORS | BioCryst Pharmaceuticals, Inc. (US) | 2023-05-17 | — | — | EP | disclosed |
| EP-3828173-A1 | SUBSTITUTED PYRAZOLES AS HUMAN PLASMA KALLIKREIN INHIBITORS | BioCryst Pharmaceuticals, Inc. (US) | 2021-06-02 | — | — | EP | disclosed |