Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 14/20 | 0.42 |
| ▸ | JAK2 | O60674 | 13/20 | 0.42 |
| ▸ | JAK1 | P23458 | 12/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1371222 | 0.84 | JAK3 (0.60) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2326040 | 0.77 | JAK3 (0.44) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2339099 | 0.77 | SYK (0.62) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2325947 | 0.76 | JAK3 (0.44) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL14797115 | 0.75 | ATR (0.45) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2343199 | 0.75 | JAK3 (0.64) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2344083 | 0.75 | SYK (0.49) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL1369492 | 0.75 | JAK2 (0.63) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL18524723 | 0.75 | SYK (0.59) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL18524490 | 0.75 | SYK (0.41) | SYKCYP2C9JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247592-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |