Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 0.64 |
| ▸ | JAK2 | O60674 | 18/20 | 0.64 |
| ▸ | JAK1 | P23458 | 18/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2343606 | 0.84 | JAK1 (0.69) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL1370458 | 0.83 | JAK2 (0.91) | JAK3JAK2JAK1CYP2C9SYK | |
| SCHEMBL2326040 | 0.80 | JAK3 (0.44) | JAK3JAK2JAK1CYP2C9SYK | |
| SCHEMBL2345350 | 0.80 | JAK3 (0.54) | JAK3JAK2JAK1SYKTYK2 | |
| SCHEMBL2336504 | 0.79 | JAK3 (0.56) | JAK3JAK2JAK1SYK | |
| SCHEMBL2325947 | 0.79 | JAK3 (0.44) | JAK3JAK2JAK1CYP2C9SYK | |
| SCHEMBL1368770 | 0.78 | JAK1 (1.00) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL2326869 | 0.76 | JAK3 (0.41) | JAK3JAK2JAK1CYP2C9SYK | |
| SCHEMBL2342903 | 0.75 | SYK (0.45) | JAK3JAK2JAK1CYP2C9SYK | |
| SCHEMBL2344786 | 0.74 | JAK2 (0.48) | JAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247592-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |