Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 12/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23412421 | 0.80 | ALDH1A1 (0.62) | HPGDSMN1; SMN2MAPTPOLBALDH1A1 | |
| SCHEMBL23440341 | 0.80 | SMN1; SMN2 (0.61) | HPGDSMN1; SMN2MAPTPOLBALDH1A1 | |
| SCHEMBL23440431 | 0.79 | NPSR1 (0.60) | HPGDSMN1; SMN2MAPTPOLBALDH1A1 | |
| SCHEMBL23440348 | 0.77 | HPGD (0.60) | HPGDSMN1; SMN2MAPTPOLBALDH1A1 | |
| SCHEMBL23440433 | 0.75 | TDP1 (0.58) | HPGDSMN1; SMN2MAPTPOLBALDH1A1 | |
| SCHEMBL23439713 | 0.75 | HPGD (0.60) | HPGDSMN1; SMN2MAPTPOLBALDH1A1 | |
| SCHEMBL23440346 | 0.75 | HPGD (0.56) | HPGDSMN1; SMN2MAPTPOLBALDH1A1 | |
| SCHEMBL28908446 | 0.75 | ALDH1A1 (0.67) | HPGDSMN1; SMN2MAPTPOLBALDH1A1 | |
| SCHEMBL30639190 | 0.75 | HPGD (0.69) | HPGDSMN1; SMN2MAPTPOLBALDH1A1 | |
| SCHEMBL23440117 | 0.73 | HPGD (0.51) | HPGDSMN1; SMN2MAPTPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021105906-A1 | ARYL AND HETEROARYL COMPOUNDS, AND THERAPEUTIC USES THEREOF IN CONDITIONS ASSOCIATED WITH THE ALTERATION OF THE ACTIVITY OF GALACTOCEREBROSIDASE | GAIN THERAPEUTICS SA (CH) | 2021-06-03 | — | — | WO | disclosed |