Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23442629 | 0.92 | USP2 (0.38) | KDM1AMRGPRX4PTGDRPTGDR2KDM4C | |
| SCHEMBL23442632 | 0.90 | CYP1A2 (0.38) | ALDH1A1MEN1CYP2C19KMT2ANPC1 | |
| SCHEMBL23669600 | 0.86 | KDM4C (0.40) | KDM1AMCL1MRGPRX4SRD5A1SRD5A2 | |
| SCHEMBL17558512 | 0.86 | KDM4E (0.39) | TTRKDM4EMAPTALDH1A1POLB | |
| SCHEMBL26314548 | 0.86 | KDM4E (0.39) | TTRKDM4EMAPTALDH1A1POLB | |
| SCHEMBL23671128 | 0.85 | KDM4C (0.37) | KDM1AMCL1MRGPRX4SRD5A1SRD5A2 | |
| SCHEMBL26731640 | 0.84 | CA1 (0.35) | KDM1AALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23670689 | 0.83 | KDM4C (0.37) | KDM1AMRGPRX4SRD5A1SRD5A2PTGDR | |
| SCHEMBL23442626 | 0.81 | KDM1A (0.41) | KDM1AMCL1MRGPRX4SRD5A1SRD5A2 | |
| SCHEMBL29554530 | 0.81 | ABL1 (0.36) | KDM1AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11760736-B2 | Processes and intermediates for preparing MCL1 inhibitors | GILEAD SCIENCES, INC. (US) | 2023-09-19 | — | — | US | disclosed |
| US-11760736-B2 | Processes and intermediates for preparing MCL1 inhibitors | GILEAD SCIENCES, INC. (US) | 2023-09-19 | — | — | US | disclosed |
| US-20230013713-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | GILEAD SCIENCES, INC. | 2023-01-19 | — | — | US | disclosed |
| US-11325891-B2 | Processes and intermediates for preparing MCL1 inhibitors | GILEAD SCIENCES, INC. (US) | 2022-05-10 | — | — | US | disclosed |
| US-20210179570-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | GILEAD SCIENCES, INC. | 2021-06-17 | — | — | US | disclosed |
| WO-2021108254-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2021-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11760736-B2 | Processes and intermediates for preparing MCL1 inhibitors | MCL1, BAK1, BCL3 | KDM1A 563/4885MCL1 1/4885MRGPRX4 3784/4885 |
| US-20210179570-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | MCL1, BAK1, BCL3 | KDM1A 563/4885MCL1 1/4885MRGPRX4 3784/4885 |
| US-11325891-B2 | Processes and intermediates for preparing MCL1 inhibitors | MCL1, BAK1, BCL3 | KDM1A 563/4885MCL1 1/4885MRGPRX4 3784/4885 |
| US-20230013713-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS | MCL1, BAK1, BCL3 | KDM1A 563/4885MCL1 1/4885MRGPRX4 3784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.