Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
| ▸ | BRAF | P15056 | 2/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | RARB | P10826 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2350685 | 0.96 | MAPK14 (0.66) | MAPK14NPC1TP53PKMMAPK1 | |
| SCHEMBL2349122 | 0.90 | MAPK14 (0.62) | MAPK14NPC1TP53PKMMAPK1 | |
| SCHEMBL12459071 | 0.86 | NPC1 (0.74) | MAPK14NPC1TP53PKMMAPK1 | |
| SCHEMBL2345369 | 0.85 | RARB (0.66) | MAPK14NPC1TP53PKMMAPK1 | |
| SCHEMBL2346857 | 0.84 | MAPT (0.64) | MAPK14NPC1TP53PKMMAPK1 | |
| SCHEMBL2345296 | 0.84 | MAPK14 (0.55) | MAPK14NPC1TP53PKMMAPK1 | |
| SCHEMBL2352480 | 0.84 | PKM (0.70) | MAPK14NPC1TP53PKMMAPK1 | |
| SCHEMBL2342393 | 0.83 | MAPK14 (0.71) | MAPK14NPC1TP53PKMMAPK1 | |
| SCHEMBL12459070 | 0.82 | NPC1 (0.58) | MAPK14NPC1TP53PKMMAPK1 | |
| SCHEMBL2350900 | 0.82 | MAPK14 (0.62) | MAPK14NPC1TP53PKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008303-B2 | e.g. 6-Methyl-biphenyl-3,4'-dicarboxylic acid 4'-[(3-bromo-phenyl)-amide]-[(4 morpholin-4-yl-phenyl)-amide]; viricide; with other active viricide such as interferon or ribavirin | ASTRAZENECA AB (SE) | 2011-08-30 | — | — | US | disclosed |