Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 6/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23446462 | 0.86 | HDAC1 (0.47) | PIK3C3SMN1; SMN2KDM4ENPC1HSD17B10 | |
| SCHEMBL23410473 | 0.83 | MAPT (0.56) | GSK3BDYRK1AKCNH2CYP2C9CYP2C19 | |
| SCHEMBL22511353 | 0.83 | RAB9A (0.59) | PIK3C3GSK3BDYRK1AKCNH2CYP2C9 | |
| SCHEMBL24883483 | 0.83 | GSK3B (0.49) | PIK3C3GSK3BDYRK1AKCNH2CYP2C9 | |
| SCHEMBL12992897 | 0.83 | BLM (0.45) | PIK3C3GSK3BDYRK1AKCNH2CYP2C9 | |
| SCHEMBL1833550 | 0.80 | AXL (0.54) | — | |
| SCHEMBL13860857 | 0.80 | AXL (0.47) | PIK3C3GSK3BDYRK1AKCNH2SMN1; SMN2 | |
| SCHEMBL4324348 | 0.80 | AXL (0.45) | PIK3C3GSK3BDYRK1AKCNH2SMN1; SMN2 | |
| SCHEMBL4944882 | 0.80 | GSK3B (0.47) | PIK3C3GSK3BDYRK1AKCNH2CYP2C9 | |
| SCHEMBL15986888 | 0.80 | TSHR (0.58) | GSK3BDYRK1AGAASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021105474-A1 | NEW COMPOUNDS FOR TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION | Facio Intellectual Property B.V. (NL) | 2021-06-03 | — | — | WO | disclosed |
| WO-2021105481-A1 | NOVEL COMPOUNDS FOR TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION | Facio Intellectual Property B.V. (NL) | 2021-06-03 | — | — | WO | disclosed |