Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 10/20 | 0.55 |
| ▸ | SYK | P43405 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14655483 | 0.88 | ATR (0.44) | JAK3SYKCYP2C9JAK2MAPK1 | |
| SCHEMBL2276900 | 0.87 | JAK3 (0.44) | JAK3SYKCYP2C9JAK2JAK1 | |
| SCHEMBL2278709 | 0.86 | JAK3 (0.55) | JAK3SYKCYP2C9MAPK1PRKCI | |
| SCHEMBL2281125 | 0.85 | JAK3 (0.54) | JAK3SYKCYP2C9MAPK1PRKCI | |
| SCHEMBL2344634 | 0.84 | JAK3 (0.41) | JAK3SYKCYP2C9JAK2JAK1 | |
| SCHEMBL2273872 | 0.84 | SYK (0.58) | SYKKCNH2 | |
| SCHEMBL2278520 | 0.84 | JAK3 (0.55) | JAK3SYKCYP2C9MAPK1PRKCI | |
| SCHEMBL2278185 | 0.83 | JAK3 (0.40) | JAK3SYKCYP2C9MAPK1PRKCI | |
| SCHEMBL2281146 | 0.83 | JAK3 (0.44) | JAK3SYKCYP2C9JAK2JAK1 | |
| SCHEMBL2275354 | 0.83 | JAK3 (0.40) | JAK3SYKCYP2C9JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |