Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.41 |
| ▸ | SYK | P43405 | 4/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276900 | 0.88 | JAK3 (0.44) | JAK3SYKCYP2C9PRKCIMAPK1 | |
| SCHEMBL2281146 | 0.88 | JAK3 (0.44) | JAK3SYKFFAR4CYP2C9PRKCI | |
| SCHEMBL14655483 | 0.86 | ATR (0.44) | JAK3SYKFFAR4CYP2C9PRKCI | |
| SCHEMBL2344632 | 0.84 | JAK3 (0.55) | JAK3SYKCYP2C9PRKCIMAPK1 | |
| SCHEMBL2278709 | 0.84 | JAK3 (0.55) | JAK3SYKCYP2C9PRKCIMAPK1 | |
| SCHEMBL2281125 | 0.83 | JAK3 (0.54) | JAK3SYKCYP2C9PRKCIMAPK1 | |
| SCHEMBL2361899 | 0.83 | JAK3 (0.39) | JAK3SYKFFAR4CYP2C9PRKCI | |
| SCHEMBL2273872 | 0.83 | SYK (0.58) | SYKKCNH2CYP2D6 | |
| SCHEMBL2278520 | 0.82 | JAK3 (0.55) | JAK3SYKCYP2C9PRKCIMAPK1 | |
| SCHEMBL2278185 | 0.82 | JAK3 (0.40) | JAK3SYKCYP2C9PRKCIMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |