Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 11/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24193618 | 0.81 | RIPK1 (0.48) | RIPK1 | |
| SCHEMBL1976309 | 0.78 | RIPK1 (0.48) | RIPK1ROCK1 | |
| SCHEMBL1977305 | 0.78 | RIPK1 (0.48) | RIPK1ROCK1 | |
| SCHEMBL1977997 | 0.78 | RIPK1 (0.48) | RIPK1ROCK1 | |
| SCHEMBL23408379 | 0.78 | RIPK1 (0.46) | RIPK1 | |
| Iodide SCHEMBL1975859 | 0.77 | RIPK1 (0.47) | RIPK1ROCK1 | |
| Hydrochloric Acid SCHEMBL1977306 | 0.77 | RIPK1 (0.47) | RIPK1 | |
| SCHEMBL26167133 | 0.75 | RIPK1 (0.62) | RIPK1 | |
| SCHEMBL19207819 | 0.73 | RIPK1 (0.66) | RIPK1 | |
| SCHEMBL26240321 | 0.73 | RIPK1 (0.54) | RIPK1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021108198-A1 | INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-06-03 | — | — | WO | disclosed |