Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | CA4 | P22748 | 2/20 | 0.56 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 5/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL11882611 | 1.00 | ALDH1A1 (0.68) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL12470284 | 1.00 | ALDH1A1 (0.68) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL8401321 | 1.00 | ALDH1A1 (0.68) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL8440721 | 1.00 | ALDH1A1 (0.68) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL8806048 | 1.00 | ALDH1A1 (0.68) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL31192522 | 1.00 | ALDH1A1 (0.68) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL6861656 | 1.00 | ALDH1A1 (0.68) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL7782710 | 1.00 | ALDH1A1 (0.68) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL31171639 | 0.98 | ALDH1A1 (0.65) | ALDH1A1CA4HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL28565770 | 0.98 | ALDH1A1 (0.65) | ALDH1A1CA4HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023066251-A1 | CONJUGATE DRUG PREPARATION, PREPARATION METHOD THEREFOR AND USE THEREOF | 同宜医药（苏州）有限公司 | 2023-04-27 | — | — | WO | disclosed |
| US-20140045739-A1 | DETERGENT COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2014-02-13 | — | — | US | disclosed |
| US-20110207646-A1 | Detergent Composition | THE PROCTER & GAMBLE COMPANY | 2011-08-25 | — | — | US | disclosed |
| EP-2155810-A2 | ALGINATE COATED, POLYSACCHARIDE GEL-CONTAINING FOAM COMPOSITE, PREPARATIVE METHODS, AND USES THEREOF | FMC Corporation (US) | 2010-02-24 | — | — | EP | disclosed |
| US-20090010983-A1 | Alginate Coated, Polysaccharide Gel-Containing Foam Composite, Preparative Methods, and Uses Thereof | FMC CORPORATION (US) | 2009-01-08 | — | — | US | disclosed |
| WO-2008157318-A2 | ALGINATE COATED, POLYSACCHARIDE GEL-CONTAINING FOAM COMPOSITE, PREPARATIVE METHODS, AND USES THEREOF | FMC CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |
| EP-1988942-A2 | GELLED COMPOSITE | FMC Biopolymer AS (NO) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007103209-A2 | GELLED COMPOSITE | FMC BIOPOLYMER AS (NO) | 2007-09-13 | — | — | WO | disclosed |
| EP-0871801-A1 | ELECTROPLATING PROCESSES COMPOSITIONS AND DEPOSITS | ENTHONE-OMI, Inc. (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1997017482-A1 | ELECTROPLATING PROCESSES COMPOSITIONS AND DEPOSITS | ENTHONE-OMI INC. (US) | 1997-05-15 | — | — | WO | disclosed |
| EP-0523136-A1 | FABRIC CLEANING PROCESS | THE PROCTER & GAMBLE COMPANY (US) | 1993-01-20 | — | — | EP | disclosed |
| WO-1991015566-A1 | FABRIC CLEANING PROCESS | THE PROCTER & GAMBLE COMPANY (US) | 1991-10-17 | — | — | WO | disclosed |