Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2340013 | 0.90 | PIK3CA (0.37) | PIK3CAPGK1PDGFRBPDGFRAPIK3CD | |
| SCHEMBL2340560 | 0.87 | NPC1 (0.41) | PIK3CAPDGFRBPDGFRAPIK3CDMTOR | |
| SCHEMBL2451300 | 0.80 | HTR3A (0.38) | PIK3CAIGF1RCNR2NPC1RAB9A | |
| SCHEMBL2345725 | 0.78 | PIK3CA (0.41) | PIK3CAPDGFRBPDGFRAPIK3CDMTOR | |
| SCHEMBL2344399 | 0.73 | PDE10A (0.34) | FPR1FPR2 | |
| SCHEMBL121817 | 0.73 | NPC1 (0.38) | NPC1RAB9AMAPTFPR1FPR2 | |
| SCHEMBL2449304 | 0.72 | CYP11B1 (0.38) | PIK3CAPIK3CDMTORIGF1R | |
| SCHEMBL1225560 | 0.69 | MEN1 (0.39) | NPC1RAB9AMAPTFPR2ALDH1A1 | |
| SCHEMBL2342861 | 0.69 | MEN1 (0.35) | PIK3CDNPC1RAB9ACYP2A6KDM4E | |
| SCHEMBL2339990 | 0.68 | KDM4E (0.50) | MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110224252-A1 | NOVEL IMIDAZOLE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2011-09-15 | — | — | US | claimed |
| EP-2201000-B1 | NOVEL IMIDAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-08-31 | — | — | EP | claimed |
| EP-2201000-A1 | NOVEL IMIDAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2010-06-30 | — | — | EP | claimed |
| WO-2009053102-A1 | NOVEL IMIDAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-04-30 | — | — | WO | claimed |
| EP-2053045-A1 | Novel imidazole derivatives | Syngenta Participations AG (CH) | 2009-04-29 | — | — | EP | claimed |
| US-20110224252-A1 | NOVEL IMIDAZOLE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2011-09-15 | — | — | US | disclosed |
| EP-2201000-B1 | NOVEL IMIDAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-08-31 | — | — | EP | disclosed |
| EP-2201000-A1 | NOVEL IMIDAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009053102-A1 | NOVEL IMIDAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-04-30 | — | — | WO | disclosed |
| EP-2053045-A1 | Novel imidazole derivatives | Syngenta Participations AG (CH) | 2009-04-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224252-A1 | NOVEL IMIDAZOLE DERIVATIVES | C1R, CBR3, C3AR1 | PIK3CA 2929/4885PGK1 4583/4885PDGFRB 4310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.