Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2778004 | 0.76 | ROCK2 (0.81) | ROCK2ROCK1 | |
| SCHEMBL19886640 | 0.71 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL1105008 | 0.71 | ROCK2 (0.65) | ROCK2ROCK1 | |
| SCHEMBL16457017 | 0.71 | ROCK2 (0.65) | ROCK2ROCK1 | |
| SCHEMBL19886641 | 0.70 | ROCK2 (0.70) | ROCK2ROCK1 | |
| SCHEMBL2776144 | 0.69 | ROCK2 (0.83) | ROCK2ROCK1 | |
| SCHEMBL19886627 | 0.68 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL16819088 | 0.67 | ROCK2 (0.79) | ROCK2ROCK1 | |
| SCHEMBL2777096 | 0.66 | ROCK2 (0.78) | ROCK2 | |
| SCHEMBL114756 | 0.66 | ROCK2 (1.00) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3828172-A1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | Aerie Pharmaceuticals, Inc. (US) | 2021-06-02 | — | — | EP | disclosed |