SCHEMBL23453402

SCHEMBL23453402

C=CNc1c(C)cccc1C(=O)NC1CCC(=O)NC1=O

nearest known ligand 0.57

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 20/20 0.57
DDB1 Q16531 4/20 0.52
BRD4 O60885 2/20 0.50
IKZF3 Q9UKT9 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23267776 0.82 CRBN (0.72) CRBNDDB1BRD4IKZF3
SCHEMBL20812183 0.82 CRBN (0.72) CRBNDDB1BRD4IKZF3
SCHEMBL24832998 0.81 CRBN (0.62) CRBNDDB1BRD4IKZF3
SCHEMBL3648191 0.81 CRBN (0.70) CRBNDDB1BRD4IKZF3
SCHEMBL26972237 0.81 CRBN (0.74) CRBNDDB1BRD4IKZF3
SCHEMBL20812313 0.79 CRBN (0.64) CRBNDDB1BRD4IKZF3
SCHEMBL22511563 0.78 CRBN (0.61) CRBNDDB1BRD4IKZF3
SCHEMBL24288834 0.77 CRBN (0.65) CRBNDDB1BRD4IKZF3
SCHEMBL27325165 0.77 CRBN (0.54) CRBNDDB1BRD4IKZF3
SCHEMBL27395860 0.77 CRBN (0.58) CRBNDDB1BRD4IKZF3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021105334-A1 PIPERIDINE-2, 6-DIONE DERIVATIVES WHICH BIND TO CEREBLON, AND METHODS OF USE THEREOF CAPTOR THERAPEUTICS S.A. (PL) 2021-06-03 WO disclosed