Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 20/20 | 0.62 |
| ▸ | BRD4 | O60885 | 2/20 | 0.60 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.57 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20812183 | 0.87 | CRBN (0.72) | CRBNBRD4DDB1IKZF3 | |
| SCHEMBL23267776 | 0.87 | CRBN (0.72) | CRBNBRD4DDB1IKZF3 | |
| SCHEMBL26972237 | 0.85 | CRBN (0.74) | CRBNBRD4DDB1IKZF3 | |
| SCHEMBL3648191 | 0.85 | CRBN (0.70) | CRBNBRD4DDB1IKZF3 | |
| SCHEMBL23812319 | 0.85 | CRBN (0.69) | CRBNBRD4DDB1IKZF3 | |
| SCHEMBL20812313 | 0.83 | CRBN (0.64) | CRBNBRD4DDB1IKZF3 | |
| SCHEMBL22511563 | 0.82 | CRBN (0.61) | CRBNBRD4DDB1IKZF3 | |
| SCHEMBL24288834 | 0.81 | CRBN (0.65) | CRBNBRD4DDB1IKZF3 | |
| SCHEMBL27395860 | 0.81 | CRBN (0.58) | CRBNBRD4DDB1IKZF3 | |
| SCHEMBL23453402 | 0.81 | CRBN (0.57) | CRBNBRD4DDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023274390-A1 | BRUTON'S TYROSINE KINASE AND MUTANT DEGRADER, COMPOSITION AND APPLICATION THEREOF | 杭州和正医药有限公司 | 2023-01-05 | — | — | WO | disclosed |