SCHEMBL2345593

SCHEMBL2345593

Nc1nc(C(=O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@]1(O)F

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 7/20 0.51
ADORA3 P0DMS8 5/20 0.46
ADORA1 P30542 3/20 0.46
ADA P00813 1/20 0.45
ADORA2B P29275 3/20 0.44
CYP1A2 P05177 2/20 0.44
THPO P40225 1/20 0.44
MEN1 O00255 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
KMT2A Q03164 1/20 0.44
BLM P54132 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2337526 0.82 TYMP (0.48) ADORA1
SCHEMBL4839727 0.81 ADORA2A (0.61) ADORA2AADORA3ADORA1ADAADORA2B
SCHEMBL1888832 0.81 ADORA2A (0.61) ADORA2AADORA3ADORA1ADAADORA2B
SCHEMBL5794230 0.81 ADORA2A (0.67) ADORA2AADORA3ADORA1ADORA2BCYP1A2
SCHEMBL7897993 0.81 ADORA2A (0.67) ADORA2AADORA3ADORA1ADORA2BCYP1A2
SCHEMBL2343062 0.81 ADORA2A (0.67) ADORA2AADORA3ADORA1ADORA2BCYP1A2
SCHEMBL7525475 0.80 ADORA2A (0.66) ADORA2AADORA3ADORA1ADORA2BCYP1A2
SCHEMBL4845331 0.80 LMNA (0.64) ADORA2AADORA3ADORA1ADAADORA2B
SCHEMBL29135436 0.80 ADORA2A (0.77) ADORA2AADORA3ADORA1ADAADORA2B
SCHEMBL6399921 0.80 ADORA2A (0.77) ADORA2AADORA3ADORA1ADAADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2361923-A2 Oligoribonucleotides and ribonucleases for cleaving RNA Isis Pharmaceuticals, Inc. (US) 2011-08-31 EP disclosed
US-20100151458-A1 OLIGORIBONUCLEOTIDES AND RIBONUCLEASES FOR CLEAVING RNA ISIS PHARMACEUTICALS, INC. (US) 2010-06-17 US disclosed
US-7695902-B2 Oligoribonucleotides and ribonucleases for cleaving RNA ISIS PHARMACEUTICALS, INC. (US) 2010-04-13 US disclosed
US-7629321-B2 Oligoribonucleotides and oligoribonucleosides that have subsequences of 2'-pentoribofuranosyl nucleosides that activate dsRNase (double stranded RNAase) ISIS PHARMACEUTICALS, INC. (US) 2009-12-08 US disclosed
US-20090198047-A1 2'-Modified Oligonucleotides ISIS PHARMACEUTICALS, INC. (US) 2009-08-06 US disclosed
US-7432250-B2 Oligoribonucleotides and ribonucleases for cleaving RNA ISIS PHARMACEUTICALS, INC. (US) 2008-10-07 US disclosed
US-7432249-B2 Oligoribonucleotides and ribonucleases for cleaving RNA ISIS PHARMACEUTICALS, INC. (US) 2008-10-07 US disclosed
US-20080032945-A1 2'-MODIFIED OLIGONUCLEOTIDES ISIS PHARMACEUTICALS, INC. (US) 2008-02-07 US disclosed
US-7138517-B2 Sugar modified oligonucleotides ISIS PHARMACEUTICALS, INC. (US) 2006-11-21 US disclosed
EP-1611249-A4 OLIGORIBONUCLEOTIDES AND RIBONUCLEASES FOR CLEAVING RNA ISIS PHARMACEUTICALS INC (US) 2006-06-28 EP disclosed
US-20020165189-A1 Oligoribonucleotides and ribonucleases for cleaving RNA ISIS PHARMACEUTICALS, INC. 2002-11-07 US disclosed
US-6399754-B1 CONTAINING SULFOPHOSPHATE GROUP ISIS PHARMACEUTICALS, INC. 2002-06-04 US disclosed
US-6307040-B1 MIXED SEQUENCE OLIGONUCLEOTIDE HAVING AT LEAST ONE MODIFIED 2'-DEOXYFURANOSYL MOIETY MODIFIED BY SUBSTITUTION WITH HALO, AZIDO, AMINO, SUBSTITUTED AMINO, HALOMETHYL, CYANATO, HALOALKOXYL, ALKYL SULFIDE OR SULFONATE, NITRATE OR NITRITE ISIS PHARMACEUTICALS, INC. 2001-10-23 US disclosed
US-6262241-B1 ANTISENSE COMPOUNDS WHICH CLEAVE PHOSPHORODIESTER BONDS AND IMPROVE PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES OF OLIGONUCLEOTIDES, USEFUL IN DIAGNOSING DISEASES ISIS PHARMACEUTICALS, INC. 2001-07-17 US disclosed
EP-0928290-A4 OLIGORIBONUCLEOTIDES AND RIBONUCLEASES FOR CLEAVING RNA ISIS PHARMACEUTICALS INC (US) 2000-01-19 EP disclosed
EP-0928290-A1 OLIGORIBONUCLEOTIDES AND RIBONUCLEASES FOR CLEAVING RNA ISIS PHARMACEUTICALS, INC. (US) 1999-07-14 EP disclosed
WO-1997046570-A1 OLIGORIBONUCLEOTIDES AND RIBONUCLEASES FOR CLEAVING RNA ISIS PHARMACEUTICALS, INC. (US) 1997-12-11 WO disclosed
EP-0549615-A4 SUGAR MODIFIED OLIGONUCLEOTIDES THAT DETECT AND MODULATE GENE EXPRESSION ISIS PHARMACEUTICALS INC (US) 1997-08-27 EP disclosed
EP-0549615-A1 SUGAR MODIFIED OLIGONUCLEOTIDES THAT DETECT AND MODULATE GENE EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 1993-07-07 EP disclosed
WO-1992003568-A1 SUGAR MODIFIED OLIGONUCLEOTIDES THAT DETECT AND MODULATE GENE EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 1992-03-05 WO disclosed