Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LOX | P28300 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855188 | 0.87 | ALDH1A1 (0.42) | HTTCYP1A2KMT2AMEN1ALDH1A1 | |
| SCHEMBL1620417 | 0.84 | ALDH1A1 (0.42) | HTTCYP1A2KMT2AMEN1ALDH1A1 | |
| SCHEMBL12093549 | 0.82 | HTT (0.44) | HTTCYP1A2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17169789 | 0.82 | SMN1; SMN2 (0.38) | HTTCYP1A2ALDH1A1SMN1; SMN2LOX | |
| SCHEMBL1314802 | 0.80 | HTT (0.43) | HTTKMT2AMEN1SMN1; SMN2NPSR1 | |
| SCHEMBL16385787 | 0.80 | HTT (0.42) | HTTCYP1A2KMT2AMEN1ALDH1A1 | |
| SCHEMBL5898221 | 0.80 | ALDH1A1 (0.42) | HTTCYP1A2KMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7451596 | 0.80 | SMN1; SMN2 (0.38) | HTTCYP1A2ALDH1A1SMN1; SMN2LOX | |
| SCHEMBL12093585 | 0.80 | HTT (0.42) | HTTCYP1A2KMT2AMEN1ALDH1A1 | |
| SCHEMBL16727014 | 0.79 | SMN1; SMN2 (0.47) | HTTCYP1A2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021110656-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-10 | — | — | WO | disclosed |
| WO-2021110656-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-10 | — | — | WO | disclosed |