⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25698595 | 0.85 | MEN1 (0.44) | — | |
| SCHEMBL2880343 | 0.77 | CYP2D6 (0.33) | — | |
| SCHEMBL15519559 | 0.76 | SLC6A2 (0.32) | — | |
| SCHEMBL15519560 | 0.76 | SLC6A2 (0.32) | — | |
| SCHEMBL8073952 | 0.76 | — | — | |
| SCHEMBL12620992 | 0.76 | — | — | |
| SCHEMBL6119513 | 0.76 | — | — | |
| SCHEMBL7930977 | 0.74 | CA2 (0.30) | — | |
| SCHEMBL30999479 | 0.74 | — | — | |
| SCHEMBL18085188 | 0.74 | CA2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11685734-B2 | ATM kinase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2023-06-27 | — | — | US | disclosed |
| US-20210188827-A1 | ATM KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. | 2021-06-24 | — | — | US | disclosed |
| WO-2021113506-A1 | ATM KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. (US) | 2021-06-10 | — | — | WO | disclosed |