Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.52 |
| ▸ | RAB9A | P51151 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19274158 | 0.88 | SMN1; SMN2 (0.54) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL20386792 | 0.85 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL23472381 | 0.82 | KDM4E (0.49) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL20219591 | 0.81 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL20219598 | 0.78 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL23472289 | 0.77 | TLR7 (0.50) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL13529809 | 0.73 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL17694678 | 0.73 | KDM4E (0.78) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL7981713 | 0.71 | PDE10A (0.59) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL13195702 | 0.71 | TLR7 (0.60) | NPC1RAB9ASMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |