Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6094935 | 0.85 | POLB (0.53) | POLBALDH1A1HPGDMAPK1HTT | |
| SCHEMBL6092274 | 0.85 | POLB (0.53) | POLBALDH1A1HPGDMAPK1HTT | |
| SCHEMBL6092279 | 0.84 | POLB (0.52) | POLBALDH1A1HPGDMAPK1HTT | |
| SCHEMBL6094939 | 0.84 | POLB (0.52) | POLBALDH1A1HPGDMAPK1HTT | |
| SCHEMBL23511448 | 0.84 | POLB (0.52) | POLBALDH1A1HPGDMAPK1HTT | |
| SCHEMBL28113175 | 0.80 | POLB (0.68) | POLBALDH1A1HPGDMAPK1HTT | |
| SCHEMBL5960083 | 0.80 | KMT2A (0.72) | POLBALDH1A1HPGDMAPK1KMT2A | |
| SCHEMBL5848695 | 0.79 | POLB (0.52) | POLBALDH1A1HPGDMAPK1HTT | |
| SCHEMBL5960067 | 0.78 | SMN1; SMN2 (0.54) | POLBALDH1A1HPGDMAPK1HTT | |
| SCHEMBL4662993 | 0.77 | POLB (0.70) | POLBALDH1A1HPGDMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021178902-A1 | METHODS OF INHIBITING MASP-2 FOR THE TREATMENT AND/OR PREVENTION OF CORONAVIRUS-INDUCED ACUTE RESPIRATORY DISTRESS SYNDROME | OMEROS CORPORATION (US) | 2021-09-10 | — | — | WO | disclosed |
| WO-2021113686-A1 | MASP-2 INHIBITORS AND METHODS OF USE | OMEROS CORPORATION (US) | 2021-06-10 | — | — | WO | disclosed |