SCHEMBL28113175

SCHEMBL28113175

Nc1ccc(S(=O)(=O)NCc2ccccc2Cl)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.68
ALDH1A1 P00352 1/20 0.68
HPGD P15428 1/20 0.68
MAPK1 P28482 1/20 0.59
HTR2C P28335 1/20 0.55
HTR2B P41595 1/20 0.55
PRMT1 Q99873 2/20 0.55
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA4 P22748 1/20 0.53
CA6 P23280 1/20 0.53
CA5A P35218 1/20 0.53
CA7 P43166 1/20 0.53
CA9 Q16790 1/20 0.53
CA5B Q9Y2D0 1/20 0.53
KMT2A Q03164 3/20 0.52
MEN1 O00255 2/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
HTT P42858 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4662993 0.87 POLB (0.70) POLBALDH1A1HPGDMAPK1HTR2C
SCHEMBL29660878 0.87 POLB (0.70) POLBALDH1A1HPGDMAPK1HTR2C
SCHEMBL27472643 0.84 ALDH1A1 (0.57) POLBALDH1A1HPGDMAPK1PRMT1
SCHEMBL12793683 0.84 POLB (0.72) POLBALDH1A1HPGDMAPK1HTR2C
SCHEMBL5960083 0.84 KMT2A (0.72) POLBALDH1A1HPGDMAPK1HTR2C
SCHEMBL6094935 0.81 POLB (0.53) POLBALDH1A1HPGDMAPK1HTR2C
SCHEMBL6092274 0.81 POLB (0.53) POLBALDH1A1HPGDMAPK1HTR2C
SCHEMBL29258799 0.81 LMNA (0.60) POLBPRMT1CA12CA1CA2
SCHEMBL28113720 0.81 CA12 (0.56) POLBALDH1A1HPGDPRMT1CA12
SCHEMBL23474256 0.80 POLB (0.55) POLBALDH1A1HPGDMAPK1HTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106146358-B Method for synthesizing amino- (N-alkyl) benzene sulfonamide 南京理工大学 2018-01-23 CN disclosed
CN-106146358-A Method for synthesizing amino- (N-alkyl) benzene sulfonamide 南京理工大学 2016-11-23 CN disclosed