Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
| ▸ | CSF1R | P07333 | 4/20 | 0.47 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 7/20 | 0.44 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23482820 | 0.81 | EGFR (0.52) | EGFRCSF1RFGFR4PDGFRBKIT | |
| SCHEMBL25866203 | 0.74 | EGFR (0.46) | EGFRCSF1RFGFR4PDGFRBKIT | |
| SCHEMBL3970864 | 0.74 | FGFR1 (0.49) | FGFR4FGFR1FGFR2FGFR3PLK1 | |
| SCHEMBL5768493 | 0.72 | FGFR4 (0.57) | EGFRFGFR4PDGFRBFGFR1PDGFRA | |
| SCHEMBL3975110 | 0.71 | FGFR4 (0.61) | EGFRFGFR4PDGFRBFGFR1PDGFRA | |
| SCHEMBL3972049 | 0.71 | LCK (0.53) | EGFRCSF1RFGFR4PDGFRBFGFR1 | |
| SCHEMBL24490202 | 0.69 | FGFR4 (0.56) | FGFR4FGFR1FGFR2FGFR3FLT3 | |
| SCHEMBL3972648 | 0.69 | FGFR4 (0.57) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL3967389 | 0.68 | LCK (0.54) | EGFRCSF1RFGFR4PDGFRBFGFR1 | |
| SCHEMBL3971330 | 0.67 | LCK (0.56) | EGFRCSF1RFGFR4PDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021113651-A2 | DENDRIMER COMPOSITIONS AND METHODS FOR DRUG DELIVERY | Ashvattha Therapeutics, Inc. (US) | 2021-06-10 | — | — | WO | disclosed |
| WO-2021113657-A1 | TRIANTENNARY N-ACETYLGALACTOSAMINE MODIFIED HYDROXYL POLYAMIDOAMINE DENDRIMERS AND METHODS OF USE THEREOF | Ashvattha Therapeutics, Inc. (US) | 2021-06-10 | — | — | WO | disclosed |