Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23478071 | 0.84 | SLC6A4 (0.38) | TSHRCYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL18616763 | 0.81 | KDM4E (0.44) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL29721254 | 0.75 | CYP3A4 (0.52) | TSHRCYP2C19LMNASMN1; SMN2PKM | |
| SCHEMBL29721313 | 0.75 | CYP3A4 (0.52) | TSHRCYP2C19LMNASMN1; SMN2PKM | |
| SCHEMBL1127184 | 0.75 | CYP3A4 (0.52) | TSHRCYP2C19LMNASMN1; SMN2PKM | |
| SCHEMBL18680990 | 0.75 | ERN1 (0.38) | KDM4EALDH1A1 | |
| SCHEMBL13824011 | 0.74 | SLC6A3 (0.54) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL1804668 | 0.73 | TSHR (0.52) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL1803598 | 0.73 | KDM4E (0.68) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL1401560 | 0.72 | TSHR (0.57) | TSHRCYP1A2CYP2D6CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021110997-A1 | N-(3-(5-(PYRIMIDIN-4-YL)THIAZOL-4-YL)PHENYL)SULFONAMIDE COMPOUNDS AND THEIR USES AS BRAF INHIBITORS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2021-06-10 | — | — | WO | disclosed |