Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7149024 | 1.00 | TSHR (0.49) | TSHRTP53PRKCAALDH1A1CYP2D6 | |
| SCHEMBL27671082 | 1.00 | TSHR (0.49) | TSHRTP53PRKCAALDH1A1CYP2D6 | |
| SCHEMBL21798546 | 0.95 | TSHR (0.47) | TSHRTP53PRKCAALDH1A1CYP2D6 | |
| SCHEMBL2355030 | 0.95 | TSHR (0.47) | TSHRTP53PRKCAALDH1A1CYP2D6 | |
| SCHEMBL16271188 | 0.95 | TSHR (0.47) | TSHRTP53PRKCAALDH1A1CYP2D6 | |
| Bromide SCHEMBL8072032 | 0.94 | TSHR (0.46) | TSHRTP53PRKCAALDH1A1CYP2D6 | |
| SCHEMBL27671072 | 0.91 | TSHR (0.51) | TSHRTP53PRKCAALDH1A1CYP2D6 | |
| SCHEMBL30426029 | 0.85 | ALOX15 (0.39) | TSHRPRKCAALDH1A1NPC1RAB9A | |
| SCHEMBL30295382 | 0.85 | TDP1 (0.41) | PRKCAALDH1A1LMNATDP1KMT2A | |
| SCHEMBL7149086 | 0.85 | TDP1 (0.41) | PRKCAALDH1A1LMNATDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560982-A2 | PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION | Chemgenes Corporation (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011103468-A2 | PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION | CHEMGENES CORPORATION (US) | 2011-08-25 | — | — | WO | disclosed |
| WO-1995024185-A1 | NOVEL PYRIMIDINE NUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 1995-09-14 | — | — | WO | disclosed |