Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 13/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.60 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.60 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.42 |
| ▸ | SELE | P16581 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 4/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10238997 | 0.84 | CLK1 (0.62) | CLK1DYRK1ADYRK1BICAM1SELE | |
| SCHEMBL159986 | 0.83 | CLK1 (0.60) | CLK1DYRK1ADYRK1BICAM1SELE | |
| SCHEMBL10238986 | 0.83 | CLK1 (0.82) | CLK1DYRK1ADYRK1BLMNACLK2 | |
| SCHEMBL23480249 | 0.83 | CLK1 (0.60) | CLK1DYRK1ADYRK1BICAM1SELE | |
| SCHEMBL11888470 | 0.81 | CLK1 (0.69) | CLK1DYRK1ADYRK1BHDAC1LMNA | |
| SCHEMBL23480418 | 0.81 | HDAC1 (0.55) | CLK1DYRK1ADYRK1BHDAC1LMNA | |
| SCHEMBL23480396 | 0.81 | CLK1 (0.58) | CLK1DYRK1ADYRK1BICAM1SELE | |
| SCHEMBL23480186 | 0.81 | CLK1 (0.58) | CLK1DYRK1ADYRK1BICAM1SELE | |
| SCHEMBL3607907 | 0.80 | CLK1 (0.56) | CLK1DYRK1ADYRK1BICAM1SELE | |
| SCHEMBL10239018 | 0.79 | CLK1 (0.55) | CLK1DYRK1ADYRK1BICAM1SELE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021113679-A1 | DIMERIC COMPOUNDS AS STING AGONISTS | MERSANA THERAPEUTICS, INC. (US) | 2021-06-10 | — | — | WO | disclosed |