Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 5/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.55 |
| ▸ | CLK2 | P49760 | 2/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | SELE | P16581 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23480396 | 0.90 | CLK1 (0.58) | CLK1DYRK1ADYRK1BCLK2NPY2R | |
| SCHEMBL23480186 | 0.87 | CLK1 (0.58) | CLK1DYRK1ADYRK1BCLK2ICAM1 | |
| SCHEMBL1390862 | 0.86 | CLK1 (0.55) | CLK1DYRK1ADYRK1BCLK2CLK4 | |
| SCHEMBL10238997 | 0.82 | CLK1 (0.62) | CLK1DYRK1ADYRK1BCLK2ICAM1 | |
| SCHEMBL10239019 | 0.79 | TBXAS1 (0.53) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL23480249 | 0.79 | CLK1 (0.60) | CLK1DYRK1ADYRK1BCLK2ICAM1 | |
| SCHEMBL23480415 | 0.79 | CLK1 (0.60) | CLK1DYRK1ADYRK1BCLK2ICAM1 | |
| SCHEMBL159986 | 0.79 | CLK1 (0.60) | CLK1DYRK1ADYRK1BCLK2ICAM1 | |
| SCHEMBL10238986 | 0.79 | CLK1 (0.82) | CLK1DYRK1ADYRK1BCLK2CLK4 | |
| SCHEMBL11888470 | 0.76 | CLK1 (0.69) | CLK1DYRK1ADYRK1BCLK2NPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501804-B2 | Bicyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-08-06 | — | — | US | disclosed |
| US-20120010247-A1 | BICYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010247-A1 | BICYCLIC COMPOUND | ACACA, CPT1B, ACACB | CLK1 1651/4885DYRK1A 4791/4885DYRK1B 4819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.