Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1148139 | 0.90 | IKBKB (0.55) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL29588779 | 0.90 | IKBKB (0.55) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL2281680 | 0.88 | IKBKB (0.60) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL2281654 | 0.88 | IKBKB (0.60) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL2282387 | 0.85 | CHEK1 (0.54) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL2282382 | 0.85 | CHEK1 (0.54) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL11921317 | 0.84 | IKBKB (0.59) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL10166372 | 0.83 | ALDH1A1 (0.43) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL560462 | 0.83 | ALDH1A1 (0.43) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL2347803 | 0.83 | CHEK1 (0.49) | IKBKBJAK2JAK3CHEK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078007-B1 | IKK-BETA SERINE-THREONINE PROTEIN KINASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2011-08-31 | — | — | EP | claimed |